|
KMID : 1188320180120060714
|
|
Gut and Liver
2018 Volume.12 No. 6 p.714 ~ p.721
|
|
|
Prognostic Value of Biochemical Response Models for Primary Biliary Cholangitis and the Additional Role of the Neutrophil-to-Lymphocyte Ratio
|
|
Yoo Jeong-Ju
Cho Eun-Ju
Lee Bo-Ra
Kim Sang-Gyune
Kim Young-Seok
Lee Yun-Bin
Lee Jeong-Hoon
Yu Su-Jong
Kim Yoon-Jun
Yoon Jung-Hwan
|
|
|
Abstract
|
|
|
Background/Aims: Recently reported prognostic models for primary biliary cholangitis (PBC) have been shown to be effective in Western populations but have not been well-validated in Asian patients. This study aimed to compare the performance of prognostic models in Korean patients and to investigate whether inflammation-based scores can further help in prognosis prediction.
Methods: This study included 271 consecutive patients diagnosed with PBC in Korea. The following prognostic models were evaluated: the Barcelona model, the Paris-I/II model, the Rotterdam criteria, the GLOBE score and the UK-PBC score. The neutrophil-to-lymphocyte ratio (NLR) was analyzed with reference to its association with prognosis.
Results: For predicting liver transplant or death at the 5-year and 10-year follow-up examinations, the UK-PBC score (areas under the receiver operating characteristic curve [AUCs], 0.88 and 0.82) and GLOBE score (AUCs, 0.85 and 0.83) were significantly more accurate in predicting prognosis than the other scoring systems (all p＜0.05). There was no significant difference between the performance of the UK-PBC and GLOBE scores. In addition to the prognostic models, a high NLR (＞2.46) at baseline was an independent predictor of reduced transplant-free survival in the multivariate analysis (adjusted hazard ratio, 3.74; p＜0.01). When the NLR was applied to the prognostic models, it significantly differentiated the prognosis of patients.
Conclusions: The UK-PBC and GLOBE scores showed good prognostic performance in Korean patients with PBC. In addition, a high NLR was associated with a poorer prognosis. Including the NLR in prognostic models may further help to stratify patients with PBC.
|
|
|
KEYWORD
|
|
|
Liver cirrhosis, biliary, Prognosis, Neutrophil-to-lymphocyte ratio
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|